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[1] [2] The dosing regimen begins at 2.5 mg weekly for 4 weeks, then increases by 2.5 mg every 4 weeks as tolerated, up to a maximum of 15 mg weekly

doi: 10.1016/j.cell.2020.02.035 175 HaaseSMurerJDuschaALeeDHBaloghAGoldRet al

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This process is mediated by the Sonic Hedgehog (SHH) signaling pathway, which promotes metaplastic transformation and enhances the immunosuppressive activity of MDSCs through mechanisms involving key suppressive factors such as Arg-1 and iNOS